Pengaruh Konsentrasi Dosis Injeksi 99TCM–MDP Terhadap Kualitas Citra Kedokteran Nuklir pada Pemeriksaan Bone Scan
Main Article Content
Abstract
Research has been conducted measuring the effect of the dose concentration of syringes on the image of nuclear medicine in order to determine how much influence the dose concentration of syringes has on the image of nuclear medicine. The study was carried out on 35 patients by calculating using the half-life formula and residual dose measurements on syringes that had been used for injection using a dose calibrator. The average residual dose in the syringe was 1.488 mCi, the minimum dose was 0.442 mCi, and the maximum dose of 8.550 mCi. The average activity of the 99Tcm – MDP source injected on a bone scan examination was 11.980 mCi, the average value of postero anterior lumbar vertebrae organ pixels was 37,543, the minimum pixel value was 14,238 and the maximum pixel value was 76,524. The effect of injection dose concentration is seen in the measurement of postero anterior lumbar vertebrae organ with a pixel value of at least 14,238 pixels or 32.23% of the maximum pixel value, influencing the nuclear image, according to the European Association of Nuclear Medicine EANM standard where the vertebral picture is not clear and the visualization of the spinal details in the posterior picture is less clear, the intervertebral disc is less explicit, the appearance of the bone in the sacral region and the iliac sacro joint in the posterior view appears slightly drear. However, the dosage range for patients does not exceed 20 mCi.
Article Details
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
References
N. E. Rosilawati, I. Nasution, and T. W. Murni, “Penggunaan Radiofarmaka Untuk Diagnosa Dan Terapi Di Indonesia Dan Asas Keamanan Penggunaan Obat,” Soepra, vol. 3, no. 1, p. 60, 2018, doi: 10.24167/shk.v3i1.697.
P. A. Erba and O. Israel, “SPECT/CT in infection and inflammation,” Clin. Transl. Imaging, vol. 2, no. 6, pp. 519–535, 2014, doi: 10.1007/s40336-014-0092-9.
BAPETEN, “Pedoman Teknis Penerapan Tingkat Panduan Diagnostik Indonesia (Indonesian Diagnostic Reference Level),” no. 8, pp. 1–54, 2021.
R. Awaludin, “Radioisotop Teknesium-99m dan Kegunaannya,” Bul. Al., vol. 13, no. 2, pp. 61–66, 2011.
S. C. Saunders, Requisites. 2007.
R. Setiawati, IMEJING PADA PENYAKIT INFEKSI MUSKULOSKELETAL. Airlangga University Press, 2023.
J. C. Dickson et al., “EANM practice guideline for quantitative SPECT-CT,” Eur. J. Nucl. Med. Mol. Imaging, vol. 50, no. 4, pp. 980–995, 2023, doi: 10.1007/s00259-022-06028-9.
Chad Adams; Kevin P. Banks, “Bone Scan,” 2022. https://www.ncbi.nlm.nih.gov/books/NBK531486/.
I. N. Islami, N. R. Hidayati, T. H. A. Wibawa, I. Iswahyudi, I. Daruwati, and M. N. Subkhi, “STUDI AWAL ESTIMASI DOSIS INTERNAL 99mTc-MDP HASIL PRODUKSI PSTNT-BATAN PADA MANUSIA UNTUK DETEKSI METASTASIS DAN INFLAMASI TULANG BERBASIS UJI BIODISTRIBUSI HEWAN MODEL MENCIT,” GANENDRA Maj. IPTEK Nukl., vol. 22, no. 2, p. 85, 2019, doi: 10.17146/gnd.2019.22.2.5302.
T. B. Bartel et al., “SNMMI procedure standard for bone scintigraphy 4.0,” J. Nucl. Med. Technol., vol. 46, no. 4, pp. 398–404, 2018.
Iaea, “Quantitative Nuclear Medicine Imaging: Concepts, Requirements and Methods,” Iaea Hum. Heal. Reports, vol. 9, p. 59, 2014, [Online]. Available: http://www-pub.iaea.org/books/IAEABooks/10380/Quantitative-Nuclear-Medicine-Imaging-Concepts-Requirements-and-Methods.
G. A. Schlapper, “Measurement and Detection of Radiation,” Nucl. Technol., vol. 67, no. 1, pp. 182–183, Apr. 1984, doi: 10.13182/nt84-a33542.
E. Vañó et al., Annals of the ICRP, vol. 44, no. 1. 2015.
A. Halimatussyakdiah, D. Milvita, and F. Nazir, “Analisis Tc-99m Sestamibi Pada Perempuan Kanker Payudara Menggunakan Teknik Region of Interest (ROI) di Laboratorium In-vivo PTKMR-BATAN,” J. Fis. Unand, vol. 9, no. 4, pp. 545–549, 2021, doi: 10.25077/jfu.9.4.545-549.2020.
D. Intokiyah, T. H. A. Wibawa, I. Iswahyudi, N. R. Hidayati, I. Daruwati, and Y. S. Perkasa, “ESTIMASI DOSIS Tc-99m GLUTATION UNTUK DIAGNOSA KANKER KEPALA DAN LEHER BERDASARKAN UJI BIODISTRIBUSI HEWAN MODEL MENCIT,” J. Sains dan Teknol. Nukl. Indones., vol. 20, no. 1, p. 19, 2019, doi: 10.17146/jstni.2019.1.1.4631.
J. H. Saragih, R. Irhas, F. Nazir, and B. Santoso, “Uptake Radioaktivitas Tc-99m Mdp pada Daerah Lutut dan Sacroilliac Joints dari Pasien Kanker Prostat yang Dilakukan Pemeriksaan Bone Scan,” Pros. Pertem. Dan Present. Ilm. Penelit. Dasar Ilmu Pengetah. Dan Teknol. Nukl., no. May 2019, pp. 303–312, 2018, doi: 10.13140/RG.2.2.18915.20000.
D. A. Tunggadewi, S. L. Azmi, and B. Santosa, “Analisis Radiofarmaka Tc 99m MDP Pada Daerah Tulang Belakang Pasien Kanker Payudara,” vol. 19, 2022.
J. R. Crowley, I. Barvi, D. Greulich, and J. W. Kiser, “Detection of Excess Presence of 99mTc-MDP Near Injection Site—A Case Report,” Front. Med., vol. 8, no. September, pp. 1–6, 2021, doi: 10.3389/fmed.2021.728542.
D. S. Utaminingtiyas, J. A. E. Noor, and N. R. Hidayati, “Evaluasi Akurasi Aktivitas Tc-99m pada Single Organ dan All Organ Menggunakan Kamera Gamma Mediso Anyscan S Dual Head dan Fantom Antropomorfik,” Nat. B, vol. 3, no. 3, pp. 247–252, 2016.
T. Van den Wyngaert et al., “The EANM practice guidelines for bone scintigraphy,” Eur. J. Nucl. Med. Mol. Imaging, vol. 43, no. 9, pp. 1723–1738, 2016, doi: 10.1007/s00259-016-3415-4.
A. K. and E. T. Donald Cedar, Stacy Lott, “Assessment of bone scan image quality based on Tc99mMDP dose amount,” Journal of Nuclear Medicine Technology, 2011. https://jnm.snmjournals.org/content/52/supplement_1/2408.
W. Indriani, D. Milvita, and F. Nazir, “Uptake Radiofarmaka Tc99m MDP pada Daerah Panggul dan Kepala dalam Menentukan Metastasis Tulang Pasien Kanker Prostat,” J. Fis. Unand, vol. 6, no. 1, pp. 24–28, 2017, doi: 10.25077/jfu.6.1.24-28.2017.
Kenneth S. Krane, INTRODUCTORY NUCLEAR PHYSICS. 1988.