Analisis Bioetika Islam terhadap Non-Invasive Prenatal Testing (NIPT) dan Pengambilan Keputusan Medis pada Kasus Anomali Janin: A Review

Authors

  • Gani Putri Aryanto Universitas Nasional

DOI:

https://doi.org/10.47313/jkik.v9i2.4357

Abstract

Non-Invasive Prenatal Testing (NIPT) is a widely used prenatal screening method that enables early detection of fetal chromosomal abnormalities with minimal risk to both mother and fetus. Despite its clinical advantages, the increasing use of NIPT raises ethical concerns, particularly related to medical decision-making when fetal anomalies are identified. This article aims to review the application of NIPT and analyze ethical issues arising from prenatal decision-making through the perspective of Islamic bioethics. This study employed a narrative review method by analyzing national and international peer-reviewed journal articles published within the last five years, focusing on NIPT, ethical dilemmas, fetal anomaly management, and Islamic bioethical principles. The findings indicate that NIPT is clinically effective and ethically acceptable as a screening tool; however, challenges remain regarding informed consent, routinization of testing, reproductive autonomy, and the potential influence of screening results on decisions related to pregnancy continuation. From the perspective of Islamic bioethics, medical decision-making following NIPT should be guided by maqāṣid al-sharī‘ah, particularly the protection of life (ḥifẓ al-nafs), consideration of benefit and harm, and respect for human dignity. In conclusion, integrating Islamic bioethical values into prenatal care is essential to ensure ethical, responsible, and culturally sensitive use of NIPT in clinical practice.

Keywords: Non-Invasive Prenatal Testing (NIPT), Islamic Bioethics, Fetal Anomalies, Medical Decision-Making, Prenatal Ethics

References

Andonotopo, W., Bachnas, M. A., Pribadi, A., Alamsyah Azis, M., Aldika Akbar, M. I., Ernawati, Hariyasa Sanjaya, I. N., Putra Wiradnyana, A. A. G., Aldiansyah, D., Dewantiningrum, J., Adi Pramono, M. B., Wantania, J., Sulistyowati, S., Stanojevic, M., & Kurjak, A. (2025). Integrating NIPT and ultrasound for detecting fetal aneuploidies and abnormalities. Journal of Perinatal Medicine, 53(7), 789–802. https://doi.org/10.1515/jpm-2025-0005

Bayirli, R. (2025). The future of non-invasive prenatal testing and ethical issues. Journal of Social and Analytical Health, 4(3 SE-Review), 119–130. https://doi.org/10.5281/zenodo.14588200

Bowman-Smart, H., Gyngell, C., Mand, C., Amor, D. J., Delatycki, M. B., & Savulescu, J. (2023). Non-Invasive Prenatal Testing for “Non-Medical” Traits: Ensuring Consistency in Ethical Decision-Making. The American Journal of Bioethics : AJOB, 23(3), 3–20. https://doi.org/10.1080/15265161.2021.1996659

Horn, R. (2022). NIPT and the concerns regarding ‘routinisation.’ European Journal of Human Genetics, 30(6), 637–638. https://doi.org/10.1038/s41431-022-01053-6

Jaser, N., & Ahaddour, C. (2023). Mapping the Islamic Ethical Discourse on Prenatal Diagnosis and Termination of Pregnancy: A Methodological Analysis. Journal of Islamic Ethics, 7(1), 177–201. https://doi.org/https://doi.org/10.1163/24685542-20230091

Jayashankar, S. S., Nasaruddin, M. L., Hassan, M. F., Dasrilsyah, R. A., Shafiee, M. N., Ismail, N. A., & Alias, E. (2023). Non-Invasive Prenatal Testing (NIPT): Reliability, Challenges, and Future Directions. In Diagnostics (Vol. 13, Issue 15, p. 2570). https://doi.org/10.3390/diagnostics13152570

Rehmann-Sutter, C., Timmermans, D. R. M., & Raz, A. (2023). Non-invasive prenatal testing (NIPT): is routinization problematic? BMC Medical Ethics, 24(1), 87. https://doi.org/10.1186/s12910-023-00970-5

Vanstone, M., Cernat, A., Nisker, J., & Schwartz, L. (2018). Women’s perspectives on the ethical implications of non-invasive prenatal testing: a qualitative analysis to inform health policy decisions. BMC Medical Ethics, 19(1), 27. https://doi.org/10.1186/s12910-018-0267-4

Yu, T., Xu, X., & Wei, Q. (2025). Non-Invasive Prenatal Testing: Advances, Applications, and Limitations in Prenatal Screening. Biomedical Research and Therapy, 12(5), 7418–7423. https://doi.org/10.15419/BMRAT.V12I5.980

Published

2026-03-18

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